April 11th 2025

Minoxidil Side Effects: What Are They?

Minoxidil is one of the most commonly used drugs in the treatment of alopecia and other forms of hair loss, both in men and women. It is a vasodilator that improves blood flow to the hair follicles, thus facilitating the arrival of nutrients and oxygen to them. It has proven medical efficacy but, as with any medication, it is important to be aware of the possible side effects derived from its consumption or topical application. Below we will tell you about the possible risks associated with its use that you should take into account.

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What type of Minoxidil treatment has the least side effects?

There are two main ways to administer Minoxidil treatment: topical Minoxidil and oral Minoxidil or Minoxidil in pill form. Each of these forms has different side effects.

Side effects of topical Minoxidil

Topical Minoxidil requires direct application of the drug to the scalp, and usually has fewer systemic effects than its oral version. However, skin alterations such as hypersensitivity, itching or peeling, among others, may also occur. This is due in some cases to the presence of propylene glycol in its composition. However, the side effects of topical Minoxidil usually disappear once the treatment is stopped or the application dose is adjusted. 

Side effects of oral Minoxidil

Minoxidil tablets are the most effective for combating alopecia and hair loss. However, this Minoxidil has long-term side effects due to its absorption into the bloodstream. Among the most common side effects of oral Minoxidil are darkening or increased body hair, headache, nausea or fluid retention. These effects vary depending on each patient and the dose administered. Once the treatment is stopped or the dose is adjusted, these possible complications disappear. 

Does Minoxidil affect men and women equally?

Minoxidil can be taken by both men and women, although in different doses, and is equally effective in both cases. The side effects do not vary especially between the sexes, although they may occur in different intensity depending on the dose administered. In any case, it is essential that the treatment is supervised by medical professionals. 

In which cases is the use of Minoxidil not recommended?

The use of Minoxidil is not recommended during pregnancy and breastfeeding, or if taking medications that lower blood pressure, nor can this drug be used in conjunction with topical corticosteroids, topical retinoids, and occlusive ointments. It is a drug that requires the supervision and prescription of a medical professional.

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